Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer / 한국유방암학회지

PURPOSE: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy (NACT) is still unclear. In this study, we assessed the role of Tau protein expression in predicting a pathological complete response (pCR) to NACT for different subtypes of breast cancer.METHODS: Four hundred and sixty-eight eligible patients were retrospectively recruited in our study. The relationship between clinicopathologic factors, including Tau protein expression, and pCR in different subtypes was evaluated using logistic regression analysis. Correlation between Tau and disease-free survival (DFS) and overall survival (OS) was performed using Kaplan–Meier analysis.RESULTS: The expression of Tau protein was negatively correlated with pCR, especially in triple-negative breast cancer (TNBC). No significant difference was observed in the luminal human epidermal growth factor receptor-2 (HER2)-negative subtype and HER2-positive subtype. Patients with pCR were associated with better DFS and OS (p < 0.05). However, Tau protein expression had no association with either DFS or OS (p > 0.05).CONCLUSION: Tau protein expression can predict pCR before NACT in TNBC, but there was no correlation between Tau expression and DFS or OS.

Erratum: Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer / 한국유방암학회지

This corrects the article “Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer” in volume 23 on page 47.This article was initially published on the Journal of Breast Cancer with a misspelled the abbreviation in figure 3. The abbreviation ‘HP’ should be corrected as ‘HR’.

Spinal Kinetic Control Based on a 6-DOF Robotic Manipulator / 医用生物力学

Objective To design and implement a control algorithm in a 6 degree of freedom (DOF) robotic manipulator, so as to simulate the spinal motion and provide stable and efficient testing plan for biomechanical tests on spinal implants. Methods The recognition method of stiffness matrix for L2-5 spinal system was firstly studied for decoupling purpose. Secondly, the direct force control system under each axial motion was established by combining the 6-axis manipulator control system with the incremental proportion integration differentiation (PID) control algorithm. By using the 6-axis direct force control system, pure moment of 7.5 N·m was applied in the direction of main motion axis to simulate flexion-extension (FE), lateral bending (LB) and axial rotation (AR) motion of L2-5 spinal segment. Results The range of motion (ROM) of L2-5 segment in FE, LB and AR direction was 23.01°,27.92°,9.81°, respectively. A 7.5 N·m pure moment could be achieved in the main motion axis, while maintaining zero force/moment in the unconstrained axis with root mean square (RMS) errors being less than 3 N and 0.1 N·m, respectively. Conclusions The proposed algorithm of direct force control using PID controller with predetermined stiffness decoupling matrix was capable of applying pure moment to the spine under FE, LB, AR motion. The research findings have a relatively high value of engineering application for various biomechanical testing of lumbar vertebrae.

Spinal Kinetic Control Based on a 6-DOF Robotic Manipulator / 医用生物力学

Objective To design and implement a control algorithm in a 6 degree of freedom (DOF) robotic manipulator, so as to simulate the spinal motion and provide stable and efficient testing plan for biomechanical tests on spinal implants. Methods The recognition method of stiffness matrix for L2-5 spinal system was firstly studied for decoupling purpose. Secondly, the direct force control system under each axial motion was established by combining the 6-axis manipulator control system with the incremental proportion integration differentiation (PID) control algorithm. By using the 6-axis direct force control system, pure moment of 7.5 N·m was applied in the direction of main motion axis to simulate flexion-extension (FE), lateral bending (LB) and axial rotation (AR) motion of L2-5 spinal segment. Results The range of motion (ROM) of L2-5 segment in FE, LB and AR direction was 23.01°,27.92°,9.81°, respectively. A 7.5 N·m pure moment could be achieved in the main motion axis, while maintaining zero force/moment in the unconstrained axis with root mean square (RMS) errors being less than 3 N and 0.1 N·m, respectively. Conclusions The proposed algorithm of direct force control using PID controller with predetermined stiffness decoupling matrix was capable of applying pure moment to the spine under FE, LB, AR motion. The research findings have a relatively high value of engineering application for various biomechanical testing of lumbar vertebrae.

Controversy on the Oddi Sphincter Function in the Treatment of Hepatolithiasis：Preservation Versus Deprivation / 中国微创外科杂志

[Summary] The controversy remains on whether the Oddi sphincter function should be preserved or deprived in the treatment of hepatolithiasis .The surgical approaches achieving both hepatobiliary lesions clearance and Oddi sphincter preservation have been widely accepted .The biliary-enterostomy is suspected to increase the risk of reflux cholangitis and cholangiocarcinoma due to iatrogenic Oddi sphincter deprivation.Endoscopic sphincterotomy (EST) as a minimally invasive method still needs further research to determine its role in hepatolithiasis management .

Study on Polyploid Induction and Identification of Nervilia fordii / 广州中医药大学学报

Objective To investigate the polyploid induction and identification of Nerviliae fordii for harvesting the polyploid plants. Methods The materials and methods for polyploid induction of Nerviliae fordii were screened separately by comparing the induction rates of rhizomes and bulbs under natural conditions and tissue culture environment, and by comparing soaking method with agar method. The effects of colchicine concentration ( 200, 300, 400, 300 mg/L), colchicine action time ( 7, 14, 21, 28 d), DMSO concentration ( 0, 10, 20, 40 mL/L) and KT concentration ( 0, 1.0, 2.0, 4.0 mg/L) on induction rate were observed by orthogonal design method. The polyploid induction in the treated plants was identified by morphology, cytology and chromosome methods. Results After the tissue culture rhizomes were treated with 300 mg/L colchicine, 10 mL/L DMSO, and 2.0 mg/L KT by agar method for 28 days, the polyploid induction rate arrived to 50%, showing better induction effect. The morphology of polyploid plants was characterized by giantism, and the leaf length, leaf width and plant height were respectively 152.17%, 158.67%and 60.90%of those of the diploid plants. The length, width and density of stoma of leaf epidermal cell as well as the number of chloroplast in the treated plants were 138.46%, 153.00%, 59.09% and 109.09% of those of the untreated plants. The results of chromosome identification showed that the amount of the tetraploid ( about 40) was 2 times of the diploid chromosome ( about 20) in the treated plants, proving that the achieved Nerviliae fordii was a tetraploid plant. Conclusion Polyploid plants of Nerviliae Fordii have been successfully obtained, which will supply evidence for improving species, richening seed-breeding resources, and selecting of improved seeds of Nerviliae fordii.